This video articulates the gist of the following: 1P-LSD or 1-propionyl-lysergic acid diethylamide is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It has been sold online as a designer drug since 2015. 1-Propanoyl-lysergic acid diethylamide (1P-LSD) appeared as a non-controlled alternative to LSD a few years ago. Although evidence is beginning to emerge from in vitro and animal studies that 1P-LSD might serve as a prodrug for LSD, an equivalent evaluation in humans is unavailable. Controlled oral and intravenous self-administrations of 100 μg 1P-LSD hemitartrate are reported in two human volunteers followed by analyses of urine and serum samples using a fully validated LC–MS/MS method. Psychometric evaluations included assessment of selected subjective drug effects and administration of the Five-Dimensions of Altered States of Consciousness rating scale (5D-ASC). In serum and urine, oral administrations of 1P-LSD only led to the detection of LSD reflecting biphasic elimination with a terminal elimination half-life of approx. t1/2 = 6.4 h. 1P-LSD could be detected for only up to 4.16 h in serum and 2.7 h in urine following intravenous administration, whereas LSD was detected in all serum samples (last sampling after approx. 24 h) and up to 80 h in urine. LSD showed first order elimination kinetics with an approx. t1/2 = 5.7 h, whereas 1P-LSD showed a rapid decrease in concentration within the first hour followed by a slower decrease, most probably due to hydrolysis. The bioavailability of LSD after oral ingestion of 1P-LSD was close to 100%. The psychosensory effects of 1P-LSD and their time course were comparable to those seen after uptake of LSD in other studies which further supports the prodrug hypothesis. The 5D-ASC scores were higher after oral compared with intravenous administration of 1P-LSD. An LSD analogue which appears to be slightly more potent with a shorter duration. Its effects are reported to be extremely similar to LSD, and thus far seems to be similarly safe. Released in late 2014, It has quickly become a highly popular research chemical due to its implicit legality, similarity to LSD and wide availability on the Internet. 1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel psychedelic substance of the lysergamide class. It is structurally related to LSD and other novel lysergamides like 1cP-LSD, 1B-LSD, and 1V-LSD. It is thought to produce its effects by stimulating serotonin receptors in the brain, although the precise mechanism is not known. 1P-LSD has been sold online as a research chemical (also called "designer drug") since 2015, but the original synthesis date of 1P-LSD is unknown. Unlike most research chemicals, it has no documented record in the research literature before its emergence on the online research chemical market in 2015. It was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD.
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No illicit substances were used in this video! This video is for informational and educational purposes only; do not try this substance or any other substance, whether it be legal or not. This video has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in an entertaining & artistic way. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information contained in this video is for general information & entertainment purposes only. By viewing this video, you agree to never recreate anything discussed whatsoever. Do not replicate anything you see or hear in this video (or any other videos posted to this channel). This video/channel does not condone or glorify the usage of drugs. Thank you & stay safe :)
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