This video articulates the gist of the following: Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal drug market. NBOMes are analogs of the 2C family of phenethylamine drugs, originally synthesized by Alexander Shulgin, that contain a N-(2-methoxy)benzyl substituent. The most frequently reported drugs from this group are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. NBOMe compounds are ultrapotent and highly efficacious agonists of serotonin 5-HT2A and 5-HT2C receptors (Ki values in low nanomolar range) with more than 1000-fold selectivity for 5-HT2A compared with 5-HT1A. They display higher affinity for 5-HT2A receptors than their 2C counterparts and have markedly lower affinity, potency, and efficacy at the 5-HT2B receptor compared to 5-HT2A or 5-HT2C. The drugs are sold as blotter papers, or in powder, liquid, or tablet form, and they are administered sublingually/buccally, intravenously, via nasal insufflations, or by smoking. Since their introduction in the early 2010s, numerous reports have been published on clinical intoxications and fatalities resulting from the consumption of NBOMe compounds. Commonly observed adverse effects include visual and auditory hallucinations, confusion, anxiety, panic and fear, agitation, uncontrollable violent behavior, seizures, excited delirium, and sympathomimetic signs such mydriasis, tachycardia, hypertension, hyperthermia, and diaphoresis. Rhabdomyolysis, disseminated intravascular coagulation, hypoglycemia, metabolic acidosis, and multiorgan failure were also reported. This survey provides an updated overview of the pharmacological properties, pattern of use, metabolism, and desired effects associated with NBOMe use. Special emphasis is given to cases of non-fatal and lethal intoxication involving these compounds. As the analysis of NBOMes in biological materials can be challenging even for laboratories applying modern sensitive techniques, this paper also presents the analytical methods most commonly used for detection and identification of NBOMes and their metabolites. N-Bomb, Bom-25, 2C-I-NBOMe, 25-I-NBOMe, 25I, Pandora, Solaris, Divination, Wizard, and Smiley Paper are slang names. There are concerns that NBOMes may sometimes be incorrectly sold as other drugs, such as LSD.
#NBOMe #Psychedelic #Tabs
⚠⚠**DISCLAIMER / WARNING**⚠⚠
No illicit substances were used in this video! This video is for informational and educational purposes only; do not try this substance or any other substance, whether it be legal or not. This video has been created strictly for education and harm reduction; to help people remain safe by properly educating them about the dangers & truths in an entertaining & artistic way. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information contained in this video is for general information & entertainment purposes only and does not replace a consultation with your own doctor/mental health professional. By viewing this video, you agree to never recreate anything discussed whatsoever. Do not replicate anything you see or hear in this video (or any other videos posted to this channel). This video/channel does not condone or glorify the usage of drugs. Thank you & stay safe :)
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